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It also targets other cells in the pancreas to stop the glucagon signal for generating glucose in the liver.[ref] In clinical trials, GLP-1 RAs improved lipid profiles, increased satiety, slowed gastric emptying, reduced inflammation, and had neuroprotective effects.[ref] The slowing of gastric emptying and reducing inflammation may play a role in weight loss, along with the decrease in appetite and eating less

So based on that, when it comes down to this claim that GLP-1 agonists increase risk of suicidal thoughts, the verdict is

Side effects are similar to semaglutide and tirzepatide

The example schedule totals 50.4 mg across 16 weeks

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