Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)
Dietary supplementation of inulin contributes to the prevention of estrogen receptor-negative mammary cancer by alteration of gut microbial communities and epigenetic regulations
Treatment discontinuation rates due to side effects ran 4 to 7% in SURMOUNT trials, similar to placebo at 2 to 3%
Tirzepatide, a GLP-1 and GIP receptor agonist, delivers maximum effectiveness when injected into subcutaneous tissuethe fatty layer just under your skin
Acetyl-L-Carnitine (ALC) is an amino acid supplement that supports energy levels.Maintains energy production
In clinical trials, the incidence was approximately 0.23% (3 out of 1,306 participants)