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Thus, we anticipated that by utilizing the CCW16 warhead degraders of RNF4 could be designed by linking this cysteine reactive moiety to established E3 ligase ligands or to itself (homo-PROTACs) 38
Unable to persuade his employer to commit any resources into getting a patent on it, in the end Eng filed a patent himself in May 1993
PMCID: PMC7988425
The shedding typically begins 2-3 months after the nutritional deficit starts
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