However, we did not detect any changes in the transcription of glt-1 after treatment with BSO (data not shown), suggesting that xct upregulation could lead to increased extracellular glutamate levels, as observed in mice that have been gestationally exposed to arsenic (Ramos-Chvez et al., 2015
The 2024 Cureus systematic review by Jaiswal and Jawade reaches the same conclusions across more than 60 cited studies: the wound-healing cascade and the delivery enhancement are two separable mechanisms, and which one dominates depends on needle depth, needle architecture, and how the serum is introduced [1]
J Tissue Eng
In respiratory disease, cellular damage and injury is mediated by an increased oxidant burden and/or decreased antioxidant defenses
These adaptations may explain why metabolic benefits can continue to improve over weeks to months of consistent use, rather than plateauing immediately
17,22,32 The findings from these trials suggest that the adverse effects of ibuprofen on the developing lung may potentially exceed the benefits associated with PDA closure and support a shift toward expectant management rather than routine early closure
