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Activation of the GLP-1R by GLP-1 also results in recruitment of -arrestin-1 (Arr1) and -arrestin-2 (Arr2), which mediate receptor internalization and may serve as scaffolds for G protein-independent signaling ( 18, 19 )

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However, genetic disruption of different components of the ghrelin-GOAT-GHSR1a axis in mice did not have the anticipated anorectic or anti-obesity effects (151154)