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Modifiable risk factors, such as diet and exercise, are important targets for intervention in the management of T2DM [2, 3]

62% (tirzepatide) vs 37% (semaglutide) achieved 10% or greater weight loss and 42% (tirzepatide) vs 18% (semaglutide) achieved 15% or greater weight loss within a year

In those cases, addressing estrogen and other hormones more directly may be necessary

For more information about these efforts to protect patients and ensure access to safe, effective FDA-approved treatments, visit semaglutide.com

Acknowledgements We acknowledge co-funding from the Fondazione per la Ricerca Biomedica Saverio e Isabella Cianciola and from Next Generation EU, in the context of the National Recovery and Resilience Plan, Investment PE8 Project Age-It: Ageing Well in an Ageing Society

5a and Supplementary Fig