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This may further destabilize the membrane phospholipid structure (cell membrane) and alter DNA expression / Gene expression due to deficits in the enzymes Methylene Tetrahydrofolate Reductase (MTHFR) and Methionine Synthase

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may relate to cholinergic effects 2

They are quite irritating, however, the use of vitamin b1, b6 and b12 injection can effectively reduce and relieve these symptoms

However, components of obesity pathology -particularly IR and low-grade inflammation- may impair these protective mechanisms, thereby contributing to the development of SO