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Detoxification: GSH participates in the detoxification of xenobiotics and endogenous metabolites through conjugation and excretion pathways

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Its conceptual foundation came from the observation that gastric mucosa survives in an environment exposed to acid, enzymes, and mechanical stress

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(2) H 2 O 2 caused hepatocyte premature senility via activating the p53/progerin pathway, which was the p21-independent way