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Chronic low-grade inflammation (inflammaging) is increasingly recognized as a driver of age-related disease, and BPC-157s ability to modulate inflammatory pathways may have broader implications for healthy aging

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This cascade leads to follicular arrest, manifest as the characteristic polycystic ovarian morphology, and causes anovulation or oligo-ovulation

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For patients who do not have chronic kidney disease or cardiovascular disease but have at least three risk factors from Table 1 , SGLT-2 inhibitors decrease mortality with an NNT of 100 (95% CI, 67 to 167) over five years