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However, this aspect of its action is potentially problematic in PWS, since many individuals with PWS already have decreased stomach emptying rates and generally slow GI transit (which does not seem to reduce their appetite)
PMID 19664690
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A network analysis pooling nine clinical trials of SGLT-2i evaluating cardiorenal outcomes in patients with T2DM, heart failure, and/or chronic kidney disease reported that SGLT-2i reduced the occurrence of asthma serious adverse events compared to placebo [98]
