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Statins, oestrogen-containing contraceptives, and HRT can also affect levothyroxine levels

The other authors report no conflicts of interest.

How They Work Amplify Physiologic GH Pulses Each peptide increases pituitary output rather than supplying exogenous hormone, maintaining feedback controls and minimizing long-term shutdown

Importantly, tirzepatide carries a boxed warning about thyroid C-cell tumors observed in rodent studies and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Retatrutide builds on this foundation by adding glucagon receptor activation, unlocking metabolic benefits that dual-pathway treatments cannot achieve