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The cardiovascular and disease-modifying benefits seen in the 2025 studies typically emerge over months to a year of consistent use
[3] [1] Semaglutide carries a boxed warning about thyroid C-cell tumors observed in rodent studies (though human relevance remains uncertain) and is contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
Your doctor will discuss the expected treatment duration based on your specific situation
Understanding the distinction between proven side effects and unsubstantiated concerns helps patients and clinicians make informed treatment decisions based on the best available evidence
Nature 547 , 99103 (2017)
Key points: Both medications cause similar gastrointestinal side effects, most commonly nausea, diarrhoea, and constipation Side effects tend to occur early in treatment and improve over time Tirzepatide appears to have lower discontinuation rates due to side effects than liraglutide Liraglutide has a longer safety track record (approved 2015 vs 2023 for tirzepatide) Dosing and practical differences Injection frequency One of the most significant practical differences is how often you inject
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