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However, concerns exist regarding the impact of GLP-1 RAs on lean mass, particularly with respect to true skeletal muscle mass

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However, they also noted that historic literature often suffers from methodological limitations, such as small sample sizes (averaging ~36 participants) and short study durations

However, researchers found that no new or liver-related safety signals emerged. Overall, the results of this study indicate that semaglutide may help improve liver outcomes for people with MASH