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PMCID: PMC12155186
How Wegovy works Wegovy contains semaglutide, a GLP-1 receptor agonist
Statins decrease low-density lipoprotein (LDL) cholesterol levels more effectively than most of the other cholesterol-lowering drugs
Variants in FTO , the fat-mass and obesity-associated gene, along with GLP1R (the GLP-1 receptor gene that every GLP-1 compound targets), MC4R (a melanocortin receptor tied to satiety and energy balance), and TCF7L2 (a transcription factor linked to glucose homeostasis) describe the metabolic terrain a clinician is prescribing into
A total of 310 adult participants were randomly assigned to receive either active oral elecoglipron or oral placebo
However, there is evidence that it may also increase LDL cholesterol in some patients, which increases the risk of cardiovascular disease
