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Tirzepatide produces slightly greater average weight loss (20-22% vs 10-15%), but both medications work through similar mechanisms

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Last reviewed: April 2026 For research use only Not for human consumption The GLP-1 class of incretin-based research peptides has moved from a single-receptor monotherapy paradigm (liraglutide, semaglutide) to dual incretin agonism (tirzepatide) and, most recently, to triple receptor agonism combining GLP-1R, GIPR and glucagon receptor (GCGR) activity (retatrutide)

slowly depress plunger to inject peptide solution over 23 seconds