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Moreover, glutamate-dehydrogenase-mediated glutamate oxidation disagrees with the observation by Balazs (1965) that in brain mitochondria by far most of the glutamate conversion to -ketoglutarate is catalyzed by the aspartate aminotransferase, an observation confirmed in both synaptic and non-synaptic mitochondria by Berkich et al

Some plateaus last a couple of weeks, while others stretch a bit longer

The Most Commonly Reported Ones Include Gastrointestinal Symptoms Such as Nausea, Vomiting, Diarrhea, Constipation, and Abdominal Discomfort

Gastrointestinal adverse events including nausea, vomiting, and diarrhea are common with current GLP-1 agonists, leading some patients to discontinue treatment or fail to reach maximally effective doses

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What is the best way to manage constipation on GLP-1 medications