[9] Eder, K., Felgner, J., Becker, K., & Kluge, H
and (2013), A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II)
Besides improving glucose control, reducing body weight, and lowering arterial blood pressure (surrogate endpoints), the breakthroughs were the demonstration of a significant reduction in cardiovascular and renal events in patients with type 2 diabetes at high risk
10.3389/fphar.2022.814871 Front Pharmacol
Report persistent nausea, vomiting, or inability to maintain adequate nutrition or hydration
Some researchers prefer morning to avoid potential nausea interfering with sleep