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B12 deficiency can also lead to the destruction of immature red blood cells in the bone marrow, which can cause jaundice (yellowing of the skin and whites of the eyes)

Conclusion: Finding Your Optimal B12 Injection Schedule Finding the right B12 injection schedule is key to getting the most from vitamin B12 therapy

The frequency of B12 injections depends on individual needs and the severity of the deficiency

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit

42 Another RCT studied cyano-B12, 1500 g three times per day for 2 weeks (route not reported), in patients with seasonal affective disorder and found no improvements in either the B12 or the placebo group

[1] For example, if a 2 mL dose (full 200 mg thiamine, 200 mg niacinamide) is to be given IV, a nurse might mix it into 50 mL of saline and infuse over 15-30 minutes