Daily supplementation with 1 g of Spirulina platensis for 12 weeks significantly improved lipid profiles in dyslipidaemic Cretan patients, notably reducing triglycerides, LDL-C, total cholesterol, and non-HDL-C levels
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Meanwhile, a recent study reported that butyrate protected mice against diet-induced NASH and liver fibrosis development by direct inhibition of collagen synthesis in hepatic stellate cells involving suppression of specific non-canonical TGF- signaling pathways Rho-like GTPases and PI3K/AKT, and other important pro-fibrotic regulators (29)
These findings reinforce the view that obesity is a chronic, relapsing condition, and that ongoing treatment may be necessary to sustain the health benefits achieved with incretin-based therapies
Our analysis revealed that in Asia, the glucose-lowering efficacies of GLP-1RAs were equivalent in T2D patients with and without overweight/obesity
