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ATTAIN-2 (NCT05872620) was a Phase III, 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of various doses of orforglipron with placebo in adults with obesity or overweight and type 2 diabetes

While higher doses (particularly 54 mg) showed some increase in gastrointestinal-related events, these remained mild to moderate in severity and did not result in treatment discontinuation

While most people tolerate the medication well, some may experience temporary mild side effects that typically resolve within the first few weeks of treatment

Works with Diet & Exercise Best results are seen when combined with a healthy lifestyle

Studies on transected rat Achilles tendon show that BPC-157 treatment accelerates healing by promoting tendon fibroblast outgrowth from tendon explants and markedly increasing the migration potential of cultured tendon fibroblasts