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[5] [6] The effects of persistent high cortisol are wide-ranging and can include: Weight gain , particularly around the abdomen and face Insulin resistance and increased risk of type 2 diabetes Hypertension (high blood pressure) Osteoporosis and increased fracture risk Mood disturbances , including anxiety and depression Immune suppression , leading to increased infection susceptibility Muscle weakness and skin changes The relationship between cortisol and metabolic health is particularly significant
For example, one study reported that 17% of patients with celiac disease also developed HT, highlighting the importance of screening for celiac disease in all patients with HT (Wroska et al., 2024)
Animal trials show reduced ulcer severity and improved mucosal healing, but translating this to human benefit remains unproven
Regardless, the semaglutide base is being manufactured by FDA-approved manufacturers and is available to compounding pharmacies
Many patients consider it a helpful weight loss injection as part of their long-term health strategy
Dosing flexibility varies significantly between platforms
