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Molecularly, the positive feedback loop formed by inflammatory signaling pathways (e.g., NF-B/NLRP3) and ROS triggers lipid peroxidation, protein carbonylation, and oxidative nucleic acid damage such as 8-hydroxy-2-deoxyguanosine (8-OHdG) (2533)

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[6] GHK-Cu independently stimulates collagen synthesis through a TGF-beta-independent pathway involving direct promoter activation of COL1A1 and COL3A1 genes

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In vitro UFMylation assay In vitro UFMylation assays were performed according to the previous description 41

Qing H, He G, Ly PT, Fox CJ, Staufenbiel M, Cai F, et al