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Discontinuation rates are higher among lower-income groups, those with multiple health conditions, and patients over 65

## The Convenience Factor: Daily vs Weekly vs Daily-With-Rules Patient adherence is heavily influenced by dosing convenience

The remaining authors declare no competing financial interests

Several GLP-1 receptor agonists are available through the NHS and private prescription in the United Kingdom, each with distinct pharmacokinetic profiles and administration schedules

Contact your doctor or healthcare team if you experience: Persistent or severe nausea, vomiting, or diarrhoea affecting your ability to eat, drink, or function normally Signs of dehydration from persistent gastrointestinal losses, such as dizziness, light-headedness, or significantly reduced urination Signs of pancreatitis , including severe upper abdominal pain that may radiate to the back call 999 or go to your nearest A&E immediately if pain is severe Gallbladder symptoms such as right upper abdominal pain, fever, or yellowing of the skin or eyes (jaundice) Symptoms of hypoglycaemia (low blood sugar) particularly if you are also taking diabetes medications such as insulin or sulphonylureas