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The SURMOUNT clinical trial program, which included over 5,000 participants treated with Zepbound for up to 72 weeks, did not identify any confirmed cases of MTC

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This loss of immune ignorance may also rely on other IFN-induced pathways of alternative antigen formation 14,17 , e.g., post-translation modifications (PTMs), alternative transcription start sites generating an INS defective ribosomal product (DRiP) 18 and peptide cis -splicing, i.e., the fusion of non-contiguous protein fragments

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doi: 10.1097/MD.0000000000026707 107 LiKFanHJiaoYWangY

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