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Kidney disease progression, defined as an estimated glomerular filtration rate decline of 30% or more or new ESKD, was significantly less likely in the GLP-1 RA group, with a HR of 0.77

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Yet, despite their ability to sustain energetics and functionality in critical tissues, animals subjected to this fasting-refeeding cycle displayed lasting physiological changes, including a reduction in body size that persisted well into later life (Supplementary Fig

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