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We provide evidence that this targeting concept can be used to antagonize NMDA receptors specifically in GLP-1-receptor-positive neurons to reverse obesity and correct symptoms of cardiometabolic diseases in preclinical obesity models

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Body-composition research continues to show that modern incretin medications are associated with substantial fat loss, but fat-free mass loss can still occur

Potential Benefits May support normal red blood cell formation May support normal nerve function May support normal energy metabolism May play a role in normal cardiovascular function May support normal neurological function These statements reflect the role of B12 as an essential nutrient as documented in the scientific literature

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