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Studies show sequential treatment with FOXO4-DRI following doxorubicin exposure prevents accumulation of senescent cells and mitigates chemotoxicity without compromising the anti-tumor effects of chemotherapy

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This mechanism dramatically increases phosphorylation of focal adhesion kinase and paxillin proteins without changing total protein amounts[6]

Also, 500 mcg is pretty low, and since the half-life is short, it really should be dosed twice a day