Reduced Methotrexate Efficacy: Folic acid supplements, caffeine/theophylline, and some antibiotics affecting gut flora may reduce absorption or effects Other Important Interactions: Live vaccines: contraindicated (risk of severe infection) Ciclosporin: excessive immunosuppression and toxicity Mercaptopurine: increased plasma levels (dose adjustment required) Phenytoin and sodium valproate: reduced efficacy reported, monitoring of phenytoin levels recommended Theophylline: decreased clearance, monitoring of theophylline levels recommended References Methotrexate | Drugs | BNF | NICE Accessed 5/2/26 Methotrexate 10 mg Tablets Summary of Product Characteristics (SmPC) (emc) | 11723 Accessed 5/2/26 Methotrexate | Macmillan Cancer Support Accessed 5/2/26 Methotrexate Sodium (Cancer Treatment) NCI Accessed 5/2/26 Managing interactions with methotrexate NHS SPS Specialist Pharmacy Service The first stop for professional medicines advice Accessed 7/2/26 Using folic acid with methotrexate in rheumatoid arthritis NHS SPS Specialist Pharmacy Service The first stop for professional medicines advice Accessed 7/2/26 Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing GOV.UK Accessed 7/2/26

Comprehensive Care Under One Roof Weight loss doesnt happen in isolation
For example, while products may be promoted to boost or enhance GLP-1 levels, the Food and Drug Administration (FDA) prohibits marketing supplements in a manner that suggests they work as well as or better than GLP-1 drugs or that the products are safer or have fewer side effects compared to GLP-1 drugs
New research underway More trials are now starting to look at how GLP-1s might influence things like chronic inflammation or immunosuppression, both of which might contribute to cancer growth
Synedicas website claims the jabs it sells are for research purposes only
GoalBMI Wellness provides physician-supervised telehealth programs for eligible patients in participating states