In consideration of the reduced compliance of peptide GLP-1 receptor agonists due to subcutaneous injection, oral micromolecular GLP-1 receptor agonists such as orforglipron have already in clinical trials, which can reduce body weight and improve cardiac metabolism in adults with obesity (Wharton et al 2023) (Fig
( PMID: 25545186 ) Ko JW, Park KD, Lee Y, Lee JH, Hong DK (2020) Eosinophilic panniculitis following the subcutaneous injection of exenatide extended-release
The GIP component may actually buffer some of the gastrointestinal distress that GLP-1 activation alone produces
The team commends Nestl for embracing the GLP-1 phenomenon rather than fearing it
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It activates two receptor systems simultaneously: the GLP-1 receptor and the GIP receptor