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BPC-157 shows remarkable potential for addressing GERD and acid reflux by targeting the root cause rather than just masking symptoms

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FMT from PLR-RStreated mice to stroke mice reproduced these protective effects, highlighting a gut microbiotamelatonin axis as a therapeutic mechanism (Zhou et al., 2023)

doi: 10.3389/fnut.2025.1686056 Received 14 August 2025 Accepted 25 September 2025 Published 16 October 2025 Volume 12 - 2025 Edited by Mingyue Song, South China Agricultural University, China Reviewed by Ludovica Verde, University of Naples Federico II, Italy Arely Vergara-Castaeda, La Salle University of Northwest, Mexico Updates Copyright 2025 Chyliska and Maciejczyk

TB-500 upregulates VEGF and actin-binding proteins, whereas BPC-157 improves endothelial repair and vascular stability