In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)
Antibiotics: Some antibiotics may interfere with the metabolism of methylcobalamin
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S2CID 19304098
Rarely, a needle can irritate a nerve (temporary paresthesia)
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