Fibromyalgia affects up to 3% of the general population and is a syndrome characterised by widespread pain, fatigue, sleep disturbances, and cognitive dysfunction, somatic symptoms, and psychiatric disorders [90]
Morris et al
However, melatonin is not exclusively produced in the pineal gland, but it is also locally synthesized in several cells and tissues, such as the retina, the gastrointestinal tract, and the innate immune system 10
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