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Peptides typically have fewer side effects and no initial shedding phase, but minoxidil has decades more clinical data

For context, Medicaid spending on GLP-1 drugs in Pennsylvania was $1.3bn in 2025 - a whopping twice as much as the previous year

Indias GLP-1 market was valued at $150.8 million in 2025 and is projected to reach $1 billion by 2033

After 24 weeks, all groups taking retatrutide saw significant weight loss compared to the placebo group (1.6% average weight loss): 7.2% for those taking 1 mg 11.8% for those taking 4 mg after starting with 2 mg 13.9% for those taking 4 mg after starting with 4 mg 16.7% for those taking 8 mg after starting with 2 mg 17.9% for those taking 8 mg after starting with 4 mg 17.5% for those taking 12 mg after starting with 2 mg After 48 weeks, patients taking retatrutide experienced even more substantial losses: 8.7% for those taking 1 mg 16.3% for those taking 4 mg after starting with 2 mg 17.8% for those taking 4 mg after starting with 4 mg 21.7% for those taking 8 mg after starting with 2 mg 23.9% for those taking 8 mg after starting with 4 mg 24.2% for those taking 12 mg after starting with 2 mg The researchers also reported that 100% of patients taking 8 mg or 12 mg saw a weight reduction of at least 5%, and 7583% had a weight reduction of 15% or more

Notes: Monitor subjects glucose levels to prevent hypoglycemia

For researchers focused on fat loss applications , understanding this dual mechanism explains why cagrilintide alone produces meaningful but moderate weight loss (around 11.8% in phase 3 data), while the combination pushes results dramatically higher