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Finally, the FLOW trial may shed further light on the potential mechanisms involved on how GLP-1 receptor agonism could alter renal physiology, combined with future mechanistic studies that aim to find proof for the effects of GLP-1 receptor agonists on the renal risk factors/pathophysiological mechanisms related to DKD as summarized in this review

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Additive effect on kidney outcomes including macroalbuminuria was also expected from AMPLITUDE-O substudy, however, additive effect of semaglutide and SGLT2i on the composite kidney outcomes without macroalbuminuria was not indicated in the FLOW substudy [50]

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Debatri Datta September 15, 2023 Written By Dr