In view of the conflicting results presented above, future research should be conducted in larger samples
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Melanotan II acts as a non-selective agonist with nanomolar-range affinity at MC1R, MC3R, MC4R, and MC5R, with relative potencies varying by assay system but generally showing highest functional activity at MC1R and MC4R in cAMP accumulation assays using transfected cell lines
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6b), suggesting that DRD2 activation drives the interaction of -arrestin2 with PKM2 to facilitate PKM2 dimerization