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Mol Genet Metab 2011;102:315

Realistic expectations are 0.25-0.5 kg (0.5-1 lb) per week under optimal conditions, with the rate influenced by baseline body composition, dietary habits, activity level, and individual metabolic responsiveness

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In this study, PLGA was used to encapsulate liraglutide, and HA coating was applied to form the LIRA@PLGA/HA sustained-release system