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Additionally, mice exposed to MP by drinking water demonstrated increased NF-B followed by decreased Nrf2 and HO-1 in testes, suggesting this increased pro-inflammatory profile may be due to reduced Nrf2/HO-1-mediated NF-B inhibition pathways [88]
This narrative review aims to critically summarize current knowledge on the effects of MPs on bone and bone marrow and to explore potential links to human bone diseases, such as osteoporosis
The genetic regulation of immune responses, inflammatory response, liver function, bile acid metabolism, gut microbiota composition, and dysregulation in these pathways is often linked to genetic variability [44, 45, 49]
Yu, Danxia et al
doi: 10.18632/oncotarget.11424 41 LiX-RZhangQZhangK-PZhangXRuanG-TSongM-Met al
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