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Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1
It differs from the native 70 residue growth factor in two respects: glutamate at position 3 is replaced by arginine, and a hydrophobic 13 residue extension (MFPAMPLLSLFVN) is fused to the N-terminus
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Most patients describe a brief, mild sting similar to any standard injection
ins Gehirngewebe gelangt)
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