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It directly inhibited the stearoyl-CoA desaturase-1 (SCD1) protein to trigger ferroptosis of ovarian cancer, evidenced by the increased ROS, total iron, and Fe 2+ levels and downregulation of ferroptosis inhibitors (SLC7A11 and GPX4), thus suppressing cancer progression in the SKOV-3 xenograft model (Liu et al., 2022)

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Overall, these results suggest the high potential of NP4 as tumor-targeting anticancer agents

These receptors are considered to be located in the hypothalamus

Dysbiosis and the subsequent negative influence on the immune system and intestinal permeability can promote the development of inflammatory and autoimmune diseases, including thyroid diseases (110112)

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