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Potential Long-Term Risks of GLP-1s There are also potential long-term risks associated with the use of GLP-1, although further research is needed to understand these effects fully

Reductions in glutathione synthesis and tissue glutathione concentrations in aged animals (compared to younger ones) are suggestive of a potentially lower ability to respond to oxidative stress or toxin exposure (28)

Synaptic plasticity, closely linked to neurogenesis, plays a pivotal role in integrating newly formed neurons into existing neural circuits

6, Supplementary Figs S6 and S7, Table 3), although the bias towards calcium mobilisation was less apparent for the pGLP-1 at the human receptors (Fig

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