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10.1371/journal.pone.0115694 31 ChenJ.ZhuT.YuD.YanB.ZhangY.JinJ.et al (2023)
They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors
There was some increase in urinary excretion of essential minerals, especially potassium and chromium
Nature Communications , 8 , 403
10.1016/j.tips.2018.10.001 213 ShahM
However, research on acute exercise interventions remains limited, with their immediate effects, safety, and intensity-dependent relationships warranting further investigation
