Also, read the accompanying editorial by David Felson: Source Reference: Felson DT "Glucagon-like peptide-1 receptor agonists and osteoarthritis" N Engl J Med 2024
Which is safer: glutathione tablets or injections
Insights from the Study The study, led by David Liss, a research associate professor at Northwestern University Feinberg School of Medicine, uncovered an alarming pattern within the GLP-1 RA Medications class
Despite reduced appetite, patients should aim to consume regular, balanced meals containing: Adequate protein (lean meats, fish, eggs, legumes, dairy) to support muscle mass and energy metabolism Complex carbohydrates (whole grains, vegetables, fruits) for sustained energy release Healthy fats (nuts, seeds, olive oil, avocado) for satiety and nutrient absorption Micronutrients from a varied diet, particularly foods containing B vitamins, iron, and vitamin D, which are essential for energy production Small, frequent meals may be better tolerated than large portions, helping to manage nausea whilst ensuring sufficient caloric intake
As semaglutide doses escalate to one milligram and higher, weight loss typically resumes at rates of one to two pounds weekly, which represents excellent sustainable progress even if slower than peak tirzepatide results
Deacon, et al (1995)