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This ROS-induced injury can lead to apoptosis, disruptions in ion regulation, and mitochondrial dysfunction, further exacerbating the inflammatory response and tissue damage
Diabetes and kidney disease: role of oxidative stress
Hjberg PV, Vilsbll T, Rabl R et al
The concept of ferroptosis as an iron-dependent cell death pathway was later introduced through the detailed characterization of the lethal mechanisms of erastin and (1 S, 3R)-RSL3 (RSL3) [5], which target system xc and GPX4, respectively [18]
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