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In recent years, ferroptosis, a non-apoptotic iron-dependent lipid peroxide (LPO)-driven form of RCD, has been gaining attention in epilepsy research (Ye et al., 2019), emerging evidence has confirmed a role for ferroptosis in the pathogenesis of epilepsy ( 2 Molecular mechanisms of ferroptosis Ferroptosis occurs when ferroptosis-inducing factors, including iron-dependent reactive oxygen species (ROS) and LPOs, significantly override the antioxidant defense system, resulting in the lethal accumulation of LPO in cellular membranes, and ultimately membrane rupture (Tang and Kroemer, 2020