Pre-marketing studies revealed an incidence of less than 1% of hemolysis and methemoglobinemia among 703 patients
Glycan bioconjugation can be differentiated according to the techniques used to target carbohydrates: glycan metabolic engineering, glycotransferase treatment followed by glycan oxidation, endoglycosidase and transferase treatment, and ketone or azide labeling
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Infusion of selective inhibitors of PGDS, e.g., tetravalent selenium compounds, reversibly, time-and dose-dependently inhibited both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep during the daytime [194], which shows that PGDS plays a crucial role in the regulation of physiological sleep
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