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Tirzepatide (Zepbound) showed even more impressive results in the SURMOUNT-1 trial, published in the New England Journal of Medicine in 2022

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The standard weight-loss titration schedule (STEP protocol) This is the schedule used in the STEP clinical trial program, which enrolled 4,567 patients across five trials and established semaglutide as the most effective GLP-1 medication for weight loss

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