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The intricacy and multidimensionality of the mechanisms underlying brain diseases demands such an adequate analytical and generalizing tool allowing taking into account the multifactorial nature of a brain disease, involvement of cross-signaling and interaction between different brain regions and peripheral organs and tissues [85].The principal cause of many brain diseases is insufficient insulin sensitivity (insulin resistance)
(6) Pillaiyar T, Manickam M, Namasivayam V
Mullins CA, Gannaban RB, Khan MS, Shah H, Siddik MAB, Hegde VK, Reddy PH, Shin AC (2020) Neural underpinnings of obesity: the role of oxidative stress and inflammation in the brain
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