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Cresto N, Gardier C, Gubinelli F, et al
While direct head-to-head trials have not been conducted, we can examine the Phase 2 results for each medication to understand their relative efficacy
The effect was dose-dependent on NAD+ availability, not NADHgiving patients NADH directly had no effect on sirtuin activation because NADH doesn't bind to the sirtuin active site
J Egypt Natl Canc Inst
Its selectivity is its defining feature
Yet, lurking behind the promise is a growing concern
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