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In the ACHIEVE-2 trial (Phase 3, 962 adults with type 2 diabetes on metformin), Orforglipron, a novel small-molecule oral GLP-1 RA went head-to-head against Dapagliflozin, one of the most widely used SGLT2 inhibitors
GLP-1s help by: Decreasing appetite, which can lead to weight loss and reduce tongue and neck fat Decreasing airway obstruction Improving lung volume
This is expressed as a percentage called the PVC burden
This, in turn, is received by various other organs to increase insulin production, glucose uptake, even taste sensitivity
A Surgeon's Perspective, 2003
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
