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408 Preclinical and clinical research has shown metformin use is associated with improved endothelial function, lower levels of tissue factor, reduced levels of oxygen free radicals, and decreased platelet activation and aggregation

In addition to these factors, researchers also observed some non-linear associations

This mechanism provides a coupling for OXPHOS damage and compensatory glycolysis during cell damage [147]

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doi: 10.1053/j.gastro.2019.11.301 29 GryaznovaMSmirnovaYBurakovaIMorozovaPLagutinaSChizhkovPet al